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KMID : 0667720070440000457
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Report Natlonal Institute of Health
2007 Volume.44 No. 0 p.457 ~ p.459
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Construction of Korea Heath Examinee Cohort 4
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Kwak Hye-Kyoung
Ahn Youn-Jhin
Kim Sung-Soo
Park Chan
Kang Dae-Hee
Kim Dong-Il
Kim Seong-Joon
Ha Eun-Hee
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Abstract
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Purpose : The Korea Health Examinee Cohort (KOEX) is one of major types of Korea Genome Epidemiology Study(KoGES). Based on the regular health check-up system offered to all adults aged 40 years and over every two years by National Health Insurance Company (NHIC) in Korea, we are currently recruiting cohort members from ~20 centers. In 2006, further recruitment of cohort members continued to estimate the prevalence of metabolic syndrome and to evaluate the association between potential risk factors and the risk of the metabolic syndrome.
Methods : Informed consent was obtained from participants upon their visiting a study clinic. Thereafter, we drew blood in the fasting state and administered questionnaire survey. Data on general lifestyle, physical activity, diet, reproductive factors, and psychosocial variables were collected through face to face direct interview using a structured questionnaire. We performed clinical examinations to obtain data on blood pressure, EKG, and several biochemical markers. Information on anthropometric indices, such as height, weight, and waist/hip circumference,were also collected. Body fat composition were measured using Bioelectric Impedance analysis (Zeus 9.9). A biological materials with several aliquots (serum, plasma, DNA, packed erythrocytes) were stored at the central biobank for future analysis. Web-based database was developed for the efficient and reliable data entry. We forwarded result sheets to each participant, which
were generated automatically from the database on completion of data entry.
Results : From May to December 2006, 4,282 (men :1,453, women:2,829) individuals were recruited. The prevalence of metabolic syndrome was 13.7% (13.6% in men and 13.7% in women). The rates appeared increasing with age, esp. among women. The rate became higher among women than men in their sixties. For the prevalence of individual components of metabolic syndrome, high blood pressure(40.3%) appears to contribute most to the prevalence, next would be high triglyceride(34.5%) among men, and high waist circumference(39.2%) ranked as the most prevalent factor, while the next was hypertension(29.7%) among women. We analysed the relationship between socio-demographic
and lifestyles factors and the prevalence of metabolic syndrome. In multivariable analysis, the family history of hypertension was found to be a risk factor among men, while the family history of diabetes mellitus among women. Especially in women, not in men, the prevalence was higher among those with low educational attainment.
Conclusion : Further researches are strongly needed to elucidate which factors are related with the syndrome and to develop effective prevention guideline.
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KEYWORD
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Metabolic syndrome, prevalence, health examinee cohort
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